The difference between hypothyroidism and hyperthyroidism is more, usually rely on clinical symptoms and laboratory tests, under the guidance of professional doctors for a clear diagnosis of hypothyroidism and hyperthyroidism, and then develop a treatment plan. 1. Clinical manifestations: hypothyroid patients usually show low metabolic symptoms, such as fear of cold, weakness, hair loss, slow reaction, and also rough skin, pericardial effusion and mucus edema. In contrast, patients with hyperthyroidism show clinical symptoms of high metabolism, such as fear of heat, palpitations, excessive sweating, increased eating, weight loss, etc. 2. In contrast, hyperthyroidism patients show an increase in T3, T4, free T3 and free T4 levels and a decrease in TSH levels. 3. Autoantibody testing: The autoimmune disease that causes hypothyroidism is usually Hashimoto’s thyroiditis, so anti-thyroid peroxidase antibodies and anti-thyroglobulin antibodies are found to be significantly elevated during testing. The most common clinical cause of hyperthyroidism is Graves’ disease, which is usually detected by significantly elevated thyroid stimulating hormone receptor antibodies in the body; 4. Patients with hyperthyroidism have the option of oral antithyroid medication, radioactive iodine-131 therapy or surgery.