Antihypertensive drugs that can cause ankle edema are dihydropyridine calcium channel blockers, mainly nifedipine, amlodipine, nifedipine, and lacidipine. Calcium channel blockers reduce myocardial contractility by inhibiting the transmembrane transport of calcium ions, leading to a decrease in the concentration of calcium ions in the myocardium and vascular smooth muscle cells, while at the same time diastolizing vascular smooth muscle, resulting in vasodilation and a decrease in peripheral resistance. Clinically, they are mainly used in the treatment of hypertension and angina pectoris. Because the vasodilator effect of calcium channel blockers also has an effect on peripheral blood vessels, and peripheral blood vessels have the function of material exchange, after dilation, the water in the blood vessels will enter the tissues to cause peripheral edema, and the ankles are the most low-hanging parts of the organism, so the edema is the most obvious. In addition to peripheral edema, calcium channel blockers have adverse effects such as allergic reactions, headache, dyspepsia, constipation, nausea, and vomiting. When using calcium channel blockers, be sure to use the medication under the guidance of a specialist, pay attention to the monitoring of adverse reactions, and promptly go to the hospital if you feel unwell.