If a mole is picked and bleeds, it should be pressed to stop bleeding, and after stopping the bleeding, local disinfection and topical medication should be used to treat the mole. If the patient accidentally picks the nevus, resulting in local bleeding, should be timely use of sterile gauze for compression to stop bleeding. After the patient’s wound stops bleeding, iodophor can be used to disinfect the local lesions. In order to prevent infection, patients can use topical antibiotic drugs, such as mupirocin ointment, under the guidance of the doctor. If the nevus breaks and bleeds on its own, it is recommended to seek medical treatment and surgical excision in time to improve the pathological examination. Avoid scratching and stimulating the nevus to avoid provoking the nevus cells. If localized ulceration and bleeding occurs, it is necessary to consult a doctor in time and follow the doctor’s advice to carry out appropriate treatment.