Laboratory tests related to allergic reactions and clinical implications Since asthma is closely related to allergic rhinitis, knowing whether a patient has an allergic reaction or allergic rhinitis can help in the diagnosis of asthma in patients with respiratory symptoms. Confirmation of the presence of allergic reactions in asthmatic patients by skin tests or serum-specific IgE assays can help physicians understand the risk factors that lead to the development of asthma in a specific patient. 1. Allergen skin test: It is a basic test to determine the presence or absence of allergic reaction status in the subject. The test is simple, rapid, inexpensive, and highly specific. However, false-positive and false-negative results can occur if not performed properly. 2. Determination of serum-specific IgE: No more reliable than skin test results, and much more expensive. The main disadvantage of this test for assessing allergic status is that a positive result does not mean that the patient also has an allergic reaction that causes asthma symptoms in a natural situation, and some patients do not cause any clinical symptoms despite having specific IgE in the serum. The relationship between allergen exposure and clinical symptom production must be confirmed by medical history. The allergic status of patients with asthma can be confirmed by allergen skin testing or serum specific IgE assays to help understand the risk factors that contribute to the development and exacerbation of asthma in individuals and also to help determine patients who need to be given specific immunotherapy. Skin allergen test or serum specific IgE assay: the presence of an allergic reaction can help in the diagnosis of asthma and can help patients identify risk factors that cause asthma. 3. Bronchial excitation test: The results of a careful excitation test with a suspected allergen or allergy can help to understand occupational asthma-causing agents. Although it has a high diagnostic value, the test should not be routinely performed because of the risk of fatal bronchospasm.