The cause of premature ejaculation is not completely clear, but according to research, premature ejaculation is related to hormonal factors, neurobiology, prostatitis and other factors. 1. Hormonal factors: According to research, secondary premature ejaculation is associated with elevated levels of thyroid stimulating hormone and thyroid hormone. Clinically, it is found that the prevalence of secondary premature ejaculation is significantly reduced in patients with hyperthyroidism after the thyroid function is normalized. 2. Neurobiological factors: 5-hydroxytryptamine plays an important neurotransmitter role in controlling ejaculation. Primary premature ejaculation may also be due to the body’s hypersensitivity to 5-hydroxytryptamine. According to research, dopamine and oxytocin also play an important role in ejaculation. 3. Prostatitis: According to the findings of men suffering from chronic prostatitis, 30% to 80% have symptoms of premature ejaculation. The prostate gland has a role in the mechanism of ejaculation, and localized inflammation leads to secondary premature ejaculation. Premature ejaculation may also be caused by other factors that require different treatments. Patients are advised to go to regular hospitals for timely consultation and treatment for early recovery.