Vaccines are usually made of pathogenic microorganisms such as bacteria and viruses, which can cause the body to produce specific immune responses, enhance human immunity and effectively prevent the occurrence of infectious diseases. Since vaccines retain their immunogenicity, in order to prevent and reduce the occurrence of adverse reactions after vaccination, each vaccine has different special contraindications. Pregnant women who receive live vaccines may increase the risk of fetal malformation in early pregnancy; 3. fever: fever caused by any reason is not suitable for vaccination and may aggravate the disease and affect the immunization effect; 4. neurological diseases: including uncontrolled epilepsy, hysteria, sequelae of encephalitis, myelitis, etc.; 5. serious diseases: such as active tuberculosis, acute and chronic kidney disease, acute Infectious diseases, etc., to avoid aggravating the condition or causing adverse consequences such as disease transmission. In addition, women who are preparing for pregnancy, breastfeeding, and those with poor nutritional status or advanced age should be comprehensively evaluated by a doctor to see if they can be vaccinated; some vaccines have special contraindications and should be judged in conjunction with the type of vaccine.