The combination of sperm and egg is essential for successful fertilization. But if there is: sperm and egg “family does not recognize a family” or sperm and sperm “kill each other” situation, is no matter how to prepare for pregnancy is not successful. 1, the sperm is intercepted: meet “female anti-sperm antibodies” For women, male sperm, seminal plasma, is obviously a foreign body. However, under normal circumstances, women do not produce anti-sperm antibodies, but only under certain circumstances, for example, because of inflammation and damage to the female reproductive tract, antibodies are also produced in the female serum and cervical mucus. At this time, macrophages in the female reproductive tract, especially in the uterus, will cause an immune response to “self-defense”, which may cause sperm that have penetrated the cervix to become inactive, agglutinate, or die. Anti-sperm positive female patients, before the onset of most of the endometritis, vaginitis, salpingitis and other inflammatory diseases of the reproductive system. Lymphatic immunotherapy can be used to treat this condition. 2, sperm wearing a protective film: the existence of “male anti-sperm antibodies” The production of anti-sperm antibodies by men themselves is not to be ignored. In the same body, sperm and sperm will “kill each other” why? Under normal circumstances, the testes and the male reproductive tract have a strong immune barrier, and it is impossible for sperm to come into contact with their own body’s immune system, so an immune reaction rarely occurs. If the anti-sperm antibodies are positive, it can be assumed that the sperm have crossed the barrier and “crossed paths” with the body’s own immune system. This situation is also caused by disease: such as inflammation of the vas deferens or other reasons for obstruction, resulting in sperm spillage, sperm this antigen and the body’s immune system contact, their own production of antisperm antibodies (AsAb), so that sperm coagulation, braking, loss of vitality, and difficult to complete the history of the mission of combining with the egg. Anti-sperm antibodies have serious damage to sperm, will damage sperm operation, make sperm lose vitality, hinder sperm-egg combination, leading to male and female infertility. Even if the hard combination of sperm and egg fertilization is established, the sperm antigen will be carried on the embryo in the early stage, and by the action of the antibody, it may cause miscarriage and death of the fertilized egg in the process of development. 3, more than a year without conception, please consider anti-sperm antibody test The chances of immune infertility are very small compared to other causes of infertility, so many couples, and even hospitals will ignore this test. Most couples will only have this test done if there are no other medical problems. Currently, anti-sperm antibody tests are not standardized across hospitals. Some hospitals prefer to draw blood from both men and women, some only draw blood from the woman, some only draw blood from the man, and some hospitals only check seminal plasma. And the World Health Organization recommends using mixed antiglobulin reaction (MAR) of seminal plasma to check, which is the internationally preferred method. 4, clinical treatment of anti-infertility, attention to prevention is the key If diagnosed with anti-sperm antibody infertility couples do not have to be too sad, nowadays advanced medical science, clinical treatment has been methods: drug treatment. The use of immunosuppressant therapy, the most commonly used is corticosteroid hormones, according to clinical studies, the male side to eat 3 to 9 months, the pregnancy rate can be increased from 9% to 32%, but during the medication must be used condoms, thus reducing the antigenic antibody response. Artificial insemination. If medication does not work, artificial insemination can be used to increase the chances of conception by taking sperm from the male partner and injecting it between the sperm into the woman’s cervix. Some data show that the cumulative live birth rate after three inseminations is 64.3%. IVF. If artificial insemination is unsuccessful after 3-6 times, in vitro fertilization (IVF), in which in vitro fertilization is performed and the embryos are then transferred into the woman’s uterus, may be considered.