The chance of contracting hepatitis C from a needle-stick injury is 1.8%, and unlike hepatitis B needle-stick injuries where immunoglobulin and hepatitis B vaccination are available, there is no vaccine for the hepatitis C virus, and immunoglobulin and antiviral drugs are not recommended for post-needle-stick injury prophylaxis. In the unfortunate event of infection exposure, be sure to have hepatitis C antibody and liver function testing and follow-up for 4-6 months thereafter, as acute hepatitis C infection is relatively insidious, and quantitative hepatitis C virus testing can be performed 4-6 weeks after infection. If HCV-RNA is positive, antiviral therapy should be administered.