Fatty grains are large due to the sebaceous glands secretion of sebum when the ducts are blocked, resulting in the formation of a rice-like size papules, dermatology is also known as cornea, mostly occurring in the frontal face. There are several methods to remove fat grains: first, laser therapy, carbon dioxide laser or ionization therapy, topical repair with recombinant bovine alkaline fibroblast gel, to achieve the therapeutic effect. Second, needle treatment, you can use fire needles or disposable sterile needles, iodophor local disinfection after the needle puncture to squeeze out the fat particles, topical application of Bactrim or erythromycin ointment local application to prevent infection, can also play a role in the removal of fat particles. Third, salicylic acid or fruit acid peeling, these two can remove closed mouth acne and fat grains, pay attention to the concentration and frequency of drugs.