Fast-acting premature ejaculation medication varies depending on the patient’s condition and etiology. Currently, drugs commonly used in clinical practice for the treatment of premature ejaculation include local anesthetics and oral medications. 1. Local anesthetics, clinically commonly used drugs are lidocaine-proparacaine cream or aerosol. Local anesthetics can significantly improve the symptoms of premature ejaculation. Its side effects include causing erectile dysfunction, causing penile anesthesia, and also causing anesthesia of the vaginal wall of the spouse. 2. Oral medications, commonly used medications include selective 5-hydroxytryptamine reuptake inhibitors, such as dapoxetine and paroxetine. Adverse effects of oral drugs include fatigue, drowsiness, nausea, vomiting, diarrhea, etc. Younger patients (under 18 years old) or depressed patients are more at risk of suicide. Long-term use of such drugs in depressed patients increases sperm DNA breaks and decreases the probability of pregnancy. All of the above drugs are commonly used in the clinical treatment of premature ejaculation, but patients are not recommended to buy and use on their own to avoid serious adverse consequences, should be purchased and used under the guidance of a professional doctor.