A little reflection on cytomegalovirus infection

  Using a search engine and typing in the keyword: cytomegalovirus, many articles only emphasize the dangers, but do not list the prevalence of natural infection, the prevalence of immunity in the population, and the chances of a true intrauterine infection affecting the fetus.  Cytomegalovirus (CMV) is a DNA herpesvirus that is widespread in nature and has a very high prevalence of infection in the population. 55% of high-income people in the United States have been infected with CMV and are immune, 85% of low-income people are infected, and another 45% of high-income people and 15% of low-income people are not immune, but the likelihood of contracting CMV during pregnancy is only However, the likelihood of CMV infection during pregnancy is only 1-4%, of which only 40% of pregnant women transmit the virus to their fetuses, and even if they do, up to 85-90% of babies do not develop the virus. intracranial calcification, chorioretinitis, mental and motor retardation, hearing loss, thrombocytopenic purpura, hepatosplenomegaly, jaundice, and hemolytic anemia.  In conclusion, just because a mother is infected with CMV does not mean that her baby will also be infected, but if a fetal infection does occur, the consequences listed above can be quite serious. Therefore, the key issue is to clarify whether the mother really has evidence of initial CMV infection during pregnancy, and it needs to be clear whether the mother transmitted the virus to the baby. Tests to confirm the presence of intrauterine CMV infection in the fetus include puncturing the amniotic fluid for isolation and culture of CMV virus or performing PCR testing for the virus, performing umbilical vein puncture to obtain cord blood and testing for IgM antibodies to the virus, total IgM antibodies, hematocrit, platelets and transaminases.  With evidence of intrauterine infection, the couple’s wishes should be fully sought and respected in deciding whether to induce labor.