Difficulty in breathing while lying down, chest tightness and shortness of breath may be caused by compression of respiratory tract by bad sleeping posture, heart failure or asthma, etc., and appropriate treatments need to be chosen according to the corresponding causes. 1. Compression of the respiratory tract: when patients sleep, especially when sleeping on their stomachs, the respiratory tract is compressed, which affects the exchange of gases and makes it easy for them to suffer from dyspnea, chest tightness, and shortness of breath while lying down. Patients should promptly change the sleeping position, try to keep lying down, which will help promote gas exchange and relieve the above symptoms. 2. Heart failure: patients with heart failure will show symptoms such as chest tightness, shortness of breath and dyspnea when they lie down and increase the volume of return blood due to the decline in the function of the cardiac pump, which will result in bruising of the lungs. Treatment can use digoxin to strengthen the heart, furosemide, spironolactone diuretic and other symptomatic treatment. 3. Asthma: asthma is a kind of airway hyperresponsiveness disease, its clinical symptoms are mainly episodes of wheezing, chest tightness, dyspnea, etc., at night and in the early morning, so asthma patients can appear after lying down dyspnea, chest tightness, shortness of breath and other symptoms. Inhalation glucocorticosteroids such as budesonide and bronchodilators such as terbutaline can be used to relieve symptoms. Lying down dyspnea, chest tightness, shortness of breath can also be seen in other diseases. It is recommended to go to the hospital in time, improve the examination, clarify the cause of the disease, and follow the doctor’s instructions to choose the appropriate method to treat the disease.