High blood pressure and take medication can not come down, need to consider the use of drugs with the wrong, bad habits, obesity, secondary hypertension and other factors related to, in addition to stop using drugs, with the doctor to choose antihypertensive drugs, but also need to change the diet, weight control, surgical intervention and other treatments. 1. The use of drugs is not appropriate: high blood pressure can not be reduced by taking medication, do not rule out due to the drug is not appropriate factors or long-term use of contraceptives or compound licorice tablets and other drugs to raise blood pressure, should be stopped immediately, with the doctor to choose the appropriate drug treatment. 2. Bad habits: for people with high blood pressure, the reason why the medication does not come down does not exclude the influence of bad life factors, such as high sodium, low potassium and high fat diet, smoking, excessive alcohol consumption, staying up too late, excessive emotional fluctuations, do not like sports, etc., these bad habits make it difficult to control blood pressure. 3. Obesity: overweight and obesity are also the causes of hypertension, so you should control your diet, avoid eating high-fat diets, and also need to do more physical exercise to control your weight. 4. secondary hypertension: high blood pressure medication can not come down the reason, also does not exclude the possibility of secondary hypertension, such as renal vascular hypertension, can be given percutaneous renal artery formation and stent implantation treatment. Secondary hypertension caused by primary aldosteronism can be treated by surgical removal of the cancer. Sleep apnea syndrome and other diseases need to be actively treated. High blood pressure can not be lowered by taking medication, it is recommended that the patient go to the hospital cardiovascular internal medicine department in a timely manner, and cooperate with the doctor to improve the relevant examination, and then do the appropriate treatment and therapy.