The typical skin changes, such as the appearance of irregular, smooth surface lesions such as round or oval shaped, may be caused by viral infection with papilloma virus due to low autoimmunity. Generally, the treatment can be improved or cured by anti-viral and improve the immunity or with physical therapy such as freezing and laser. However, if there are recurrent attacks or large local lesions, autoimmune diseases or secondary diseases should be considered and local pathological biopsies should be performed if necessary to prevent the possibility of malignant changes or other changes. In addition, it is recommended to pay more attention to diet and rest, eat more fruits and vegetables, eat less spicy and stimulating food, stay up less, and pay more attention to exercise to improve the immune system.