In the past, there was no effective treatment for cervical high-risk HPV infection. Photodynamic therapy has brought light to the treatment of HPV infection-related diseases. The treatment principle is through the local administration of 5-ALA, the precursor substance of human ferrous heme synthesis, which can preferentially accumulate in the lesion tissue and transform into the strong photosensitive substance protoporphyrin IX, and after being irradiated by the corresponding wavelength of light, produce photodynamic effects and strong oxidizing agents such as free radicals and singlet oxygen, targeting and destroying the lesion tissue without damaging the normal tissue. HPV is an epitheliophilic virus that binds to basal cells after infection with the cervix and expresses HPV genes in the subepithelial layer of spinal cells. Wierrani et al. evaluated the efficacy of ALA-PDT in 20 patients with CIN1 and CIN2 co-infected with HPV at the first, third, sixth and ninth months of treatment and found that 19 patients were completely cured (95%). The results showed that 19 cases were completely cured (95%) and 80% of the patients were negative for the virus. High-risk HPV infection is closely related to the occurrence of cervical cancer, and more than 99% of cervical cancers are associated with high-risk HPV infection, and persistent HPV infection is the most critical factor in the occurrence of cervical cancer. Clinical practice at home and abroad proves that Ira photodynamic therapy can not only safely and effectively remove HPV-infected cervical lesions, but also the whole treatment process is non-bleeding, no anesthesia is needed, the lesion tissue can be selectively destroyed, the normal cervical structure is preserved, and reproductive function is not affected. Photodynamic therapy can treat patients who are high-risk HPV positive and have been infected for more than one year, patients who are high-risk HPV positive combined with cervical CINⅠ, and patients who are high-risk HPV positive with viral load above 100pg/mL and other related cervical symptoms. Photodynamic therapy has the following advantages compared with other methods of treating cervical high-risk HPV infection: 1, local drug application, less trauma, less systemic side effects. 2. Fast intracellular metabolism, no accumulation, and no special light avoidance. 3, good selectivity, targeted treatment of lesion tissue, no damage to the normal tissue around the lesion. 4. Repeatable treatment, no drug resistance. 5.No damage to the cervix, does not affect the function of the cervix, does not affect the patient’s reproductive function. 6.It can eliminate the hidden lesions and clear the infection in subclinical state, thus reducing the recurrence rate.