Minor triplets are those who are positive for HBsAg, anti-HBe, and anti-HBc and negative for anti-HBs and HBeAg in the five items of the hepatitis B two-way test. In the first case, there are no obvious symptoms related to hepatitis activity (i.e., no fatigue, loss of appetite, dull pain in the liver area, etc.), which are often found during physical examinations, or after an episode of hepatitis has been cured by treatment, the patient has been repeatedly examined for minor triplets, with negative HBV DNA, normal liver function and no abnormalities in ultrasound. This condition is usually stable for a long time and does not require treatment. In the second case, although it is also a small triple-positive case, there are also symptoms related to hepatitis, abnormal liver function or repeated fluctuations (ALT, AST elevated), HBV DNA positive (>3 times), liver ultrasound indicates chronic hepatitis or cirrhosis, i.e. thick liver mass, or nodules, or large spleen or portal vein widening. This condition is often due to the mutation of the pre-C region of the viral genome (caused by the pre-C mutant strain of hepatitis B virus), and should be treated urgently with antiviral therapy, as well as with appropriate hepatoprotective, enzyme-lowering, and anti-fibrotic treatment measures.