Oral medications clinically used to treat premature ejaculation premature ejaculation can take two types of 5-hydroxytryptamine reuptake inhibitors, tricyclic antidepressants. However, whether the effect can be seen directly is different from person to person. 1. 5-hydroxytryptamine reuptake inhibitors, such as dapoxetine and paroxetine, have a short half-life and are an on-demand treatment for premature ejaculation. This class of drugs is contraindicated in people with a known hypersensitivity to the product, in patients with a significant pathological condition of the heart, in patients with moderate and severe liver damage. It can also not be used in conjunction with thioridazine, strong cytochrome P450 3A4 inhibitors, monoamine oxidase inhibitors. 2. Tricyclic antidepressants, such as chlorpromazine. These drugs are mainly used for psychological premature ejaculation and can significantly relieve the symptoms of patients with psychological premature ejaculation. Side effects of the above drugs include fatigue, drowsiness, nausea, vomiting, diarrhea, etc. Younger patients (under the age of 18) or depressed patients are more at risk of suicide. It is not recommended that patients buy and take them on their own to avoid serious adverse reactions, and the drugs should be used under the guidance of a medical professional.