Skin lesions that grow like grapefruit flesh may be diseases such as condyloma acuminatum, filiform warts, and dermatofibroma. 1. Condyloma acuminatum: a sexually transmitted disease caused by human papilloma virus infection. If after unclean sex appear genitals, anus around the skin redundancy, appearance like grapefruit meat or manifestation of corns, papillary, may be acromegaly, should go to the hospital in a timely manner for examination to confirm the diagnosis. 2. filiform warts: benign skin growths caused by human papilloma virus infection may also cause skin lesions that look like grapefruit flesh. 3. Dermatofibroma: a benign skin growth, commonly found in the neck, armpits and other parts of the skin softer, smooth surface, may be manifested in the shape of grapefruit meat lesions. It is recommended that the patient go to a regular hospital to get a clear diagnosis and follow the doctor’s instructions for treatment.