Psoriasis, commonly known as psoriasis, is a chronic inflammatory skin disease with a long course and is prone to recurrence. The onset of the disease is predominantly in young adults, with clinical manifestations of erythema and scaling, which can develop all over the body, with the scalp and extremities being more common, and mostly aggravated in winter. The clinical phenotype is predominantly the common type (97.06%), with 28.43% of the patients describing a family history. According to the analysis of dermatology clinic visits, the prevalence of psoriasis in China is increasing year by year, and the severity of the disease is also on the increase, which may be related to the modern lifestyle of the Chinese population. I. Genetic research Recent studies have shown that psoriasis is an environmentally related polygenic disease involving a number of genetic polymorphisms in the immune system and abnormalities of keratin-forming cells. Genome-wide association analysis studies of psoriasis susceptibility genes have revealed that the late cornified envelope (LCE) gene cluster located on lq21 is significantly associated with psoriasis. The function of this gene is to encode the epidermal terminal differentiation keratinized envelope protein. II. Predisposing factors Mental factors: adverse emotions, such as tension, anxiety, anger, depression, etc.; emergency life events, such as family disputes, job changes, examinations, etc.; overwork and sleep disorders; smoking and heavy alcohol consumption; lack of exercise and excessive obesity; trauma and infection; seasons and temperatures: most psoriasis patients have remission in the summer, while the disease tends to recur and worsen in the fall and winter. Three, the different manifestations of psoriasis 1, common psoriasis: the most common type in the clinic, most of them are acute onset. The typical clinical features are silvery-white scales, shiny films and punctate bleeding. The lesions start as inflammatory red papules, corn to green bean in size, and then gradually expand or fuse into red plaques with clear borders, surrounded by an inflammatory red halo, with obvious basal infiltration and covered with multiple layers of dry silvery-white scales. Gently scrape away the surface scales, then reveal a layer of light red shiny translucent film, called film phenomenon. Scrape the film again, that is, to reach the top of the dermal papillary layer, where the capillaries are scraped, then small bleeding spots appear, called punctate bleeding, that is, Auspitz’s sign (Auspitz’s sign). 2. Herpetic psoriasis: it is relatively rare in clinical practice, and can be divided into two types: generalized and palmoplantar pustular psoriasis. It is often accompanied by fever, arthralgia and swelling, general discomfort and systemic symptoms such as leukocytosis and accelerated blood sedimentation, and the appearance of clusters of superficial sterile pustules on the basis of erythema, some of which can fuse to form pus lakes. It can often be complicated by liver and kidney system damage, and can also be life-threatening secondary to infection, electrolyte disorder or organ failure. The palmoplantar pustular psoriasis lesions are limited to the hands and feet, and more small sterile pustules appear on the erythematous plaques, which can be accompanied by deck damage, often occurring symmetrically. 3.Erythrodermic psoriasis: it is a kind of serious psoriasis. Often caused by the external use of strong or inappropriate stimulating drugs, corticosteroids suddenly stop or reduce the amount too quickly; clinical manifestations of exfoliative dermatitis. Flushing appears at the site of the original skin lesion, rapidly expanding, and finally the whole body skin is diffusely red, with obvious inflammation and a large number of scales attached to the surface, which is often accompanied by small islands of normal skin. Patients often have systemic symptoms such as fever, chills, headache and discomfort. The superficial lymph nodes may be enlarged, and the white blood cell count often increases. 4, arthritic psoriasis: also known as psoriatic arthritis, in addition to psoriasis-like rash, patients with this type have rheumatoid arthritis symptoms, and their joint symptoms are often aggravated or reduced at the same time as the skin symptoms. Fourth, the treatment principle 1, formal: emphasize the use of the currently recognized drugs and methods of treatment in the dermatological sciences. 2, safety: all kinds of treatment methods to ensure the safety of patients as the first priority, not to pursue the recent efficacy and ignore the occurrence of serious adverse reactions. 3.Individualization: When choosing a treatment plan, the patient’s condition, needs, tolerance, affordability, previous treatment history and adverse reactions to drugs should be taken into consideration comprehensively and reasonably. V. Patient education 1. Seek medical advice: seek medical advice from regular medical institutions, do not believe in advertisements; follow medical advice to use drugs, do not use drugs at will; it is very important to avoid seeking any “folk remedies” and “ancestral secret recipes to remove the roots”. If you say that you can go to the root must be the use of drugs with toxic side effects, the loss is not worth the gain. 2, but there is no need to be nervous and anxious, the correct face or can be well controlled, such as maintaining a good mental state, eliminate mental tension factors; maintain good habits: reasonable diet, proper exercise, improve sleep, avoid smoking and alcohol. 3, active prevention and treatment of colds and other kinds of infections. 4, daily care: frequent, regular use of moisturizing emollients, avoid scratching, hot water scalding, appropriate to wear comfortable, loose, pure cotton, light-colored clothing.