Widened spacing of incisors is one of the symptoms of Mannoside Storage Disorder Type II. Mannoside Storage Disease Type II most often develops after the age of 2 years, with normal physical and psychomotor development, progressive cerebral delay starting after the age of 2 years, frequent respiratory infections, ugly face, thick eyebrows, widened spacing of incisors, bulging jaws, low anterior hairline, and mild bilateral deafness (mostly sensory). Some patients may have allodynia. The diagnosis can be made on the basis of clinical symptoms, X-ray manifestations, recurrent infections, mental retardation, motor retardation, biopsy of the liver and other tissues showing acidic alpha-mannosidase deficiency and no excessive mucopolysaccharide excretion in the urine. 1, biochemical analysis of peripheral blood neutrophils, lymphocytes and bone marrow cells can be seen within the vacuolated liver tissue, and other tissue biopsy, biochemical analysis, showing an increase in mannan glucoside, and acid-type α-mannosidase deficiency; urine containing mannose oligosaccharides. 2.X-ray examination X-ray shows mild multiple osteogenesis imperfecta, lumbar vertebral body hypoplasia in the shape of a bird’s beak; iliac wing mild ectropion, hip ectropion deformity, widening of the ribs, epiphyseal diaphysis of the long bones, metacarpal and phalangeal bone thickening; sclerosis of the cranial vault and base of the skull, and in some cases severe scoliosis and hunchback may be seen. Differential diagnosis: Type I or infantile type has normal development at birth, but around 1 year of age, there may be progressive facial ugliness, huge tongue, flat nose, large ears, wide teeth, large head, large hands and feet, low muscle tone and slow movement of the limbs, but its degree is not as large as Hurler’s syndrome, sternal augmentation and convexity, hunchback of the thoracolumbar region, thickening of cranial bones, the cornea is generally clear, but there are also patients with cloudy crystals, and some of the patients have deafness or speech disorders in early life, and mental retardation. deafness or have speech disorders and mental retardation.