Widened spacing of incisors is one of the symptoms of Mannoside Storage Disorder Type II. Mannoside Storage Disease Type II most often develops after the age of 2 years, with normal physical and psychomotor development, progressive cerebral delay starting after the age of 2 years, frequent respiratory infections, ugly face, thick eyebrows, widened spacing of incisors, bulging jaws, low anterior hairline, and mild bilateral deafness (mostly sensory). Some patients may have allodynia. The following are daily preventive measures: 1. Increase calcium intake Research data show that in the long-term low-calcium diet, the risk of osteoporosis in old age can be more than 79%, while long-term intake of calcium-rich diets, of which only a quarter of the population suffers from osteoporosis. Therefore, calcium is best obtained from food, and even if osteoporosis has been identified, doctors will advise patients to improve their diet and take oral calcium supplements as appropriate. Everyone (especially the middle-aged and elderly) should pay great attention to calcium supplementation through food. Milk, bone broth, seafood and green leafy vegetables are rich in calcium ions that can be absorbed by the human body, and eating more of these foods is conducive to increasing calcium intake. Currently, medical nutritionists especially recommend milk, middle-aged and elderly people insist on drinking 500 milliliters of milk per day, can greatly reduce the incidence of osteoporosis. 2, adequate protein intake medical nutritionists pointed out that protein is the basic unit of human tissue cells, the maintenance of bone matrix is extremely important, if long-term low-protein diet will cause insufficient protein synthesis in the bone matrix, leading to a decline in bone density, induced osteoporosis. Therefore, medical nutritionists pointed out that middle-aged and elderly people should ensure to meet the body’s protein nutritional needs, intake of adequate food protein. Eggs, lean meat, milk, beans and fish and shrimp are all high protein food, should be reasonably matched to ensure the supply. 3, do not smoke and drink less alcohol Research shows that alcohol and tobacco in the harmful substances and their toxins can lead to osteoblast poisoning, destruction, so that the amount of bone decreased and induced osteoporosis. The survey found that nearly 80% of male patients suffering from osteoporosis of the spine have a long history of heavy smoking and alcoholism. Therefore, people should try their best not to smoke and drink less alcohol, or at least not to smoke a lot and not to abuse alcohol. Especially in middle age, must quit smoking and avoid alcohol, even if drinking alcohol is only a small amount of low alcohol such as beer, wine and liquor, and strictly control the amount and frequency of alcohol. 4.Participate actively in appropriate sports and exercise Adhere to sports and exercise can enhance the strength of the bone and bone mass. People who lack exercise for a long time will have a rapid decrease in bone mass in old age, and the risk of serious osteoporosis or even spontaneous fracture is much greater than that of people who exercise regularly. Therefore, people should develop the habit of sports from adolescence, and still arrange suitable sports and exercise programs according to the physical condition in old age, no less than 3 days a week, which can help prevent osteoporosis and reduce the occurrence of serious osteoporosis.