Under normal circumstances, fever usually returns to normal within 1-3 days after HFMD vaccination. Vaccination against HFMD can effectively prevent HFMD in children. After vaccination, the body will have a corresponding immune response, such as fever, rash, local redness and swelling. Most children’s fever can return to normal within 1-3 days, and some children can even return to normal on the day of fever without much intervention. If the fever persists and even blisters appear on the hands, feet and mouth, you need to be alert to the possibility of HFMD infection. Although the HFMD vaccine is inactivated and does not have a significant effect on the body, it may still cause HFMD depending on the individual’s constitution, so it is recommended to consult a pediatrician promptly.