What is the difference between domestically produced hyaluronic acid and imported hyaluronic acid? In recent years, the development momentum of cosmetic industry in China has been exceptionally rapid. As a big manufacturing country, the production capacity of medical hyaluronic acid (API) in China is about 80% of the world, and there are many famous manufacturers producing medical hyaluronic acid in mainland China. In fact, there is not much difference in the essence of different brands of hyaluronic acid at home and abroad, only the process and cross-linking agent used in the synthesis and processing process are different, like Juvéderm, Restylane and Elravie, these international well-known brands have unique patented technology, there is really some advantage in the product maintenance time, but the price is expensive, because the penis enlargement requires a larger amount of hyaluronic acid injection. The use of imported products will greatly increase the medical costs due to the large amount of hyaluronic acid injections needed for penis enlargement. On the contrary, domestic hyaluronic acid has a significant advantage in terms of cost effectiveness. At the same time, we cannot ignore the other two important factors that determine the effect of injection – injection technology and hyaluronic acid type. The injection technique is the core of achieving the best efficacy and is the touchstone to test the doctor’s level; in terms of material selection, if you have high requirements for maintenance time, you can choose large-molecule hyaluronic acid, which has a hard texture, good plasticity effect, and is not easily displaced after surgery, and the maintenance time is also longer. If you want to maintain the best condition, how long do you need to replenish hyaluronic acid injection? Everyone is very concerned about hyaluronic acid supplemental injections. Indeed, as a filler material that can be completely absorbed and degraded by the body, its thickening effect will eventually disappear. According to published studies at home and abroad and my personal injection experience, if the injected dose is above 10ml, its efficacy can be maintained for 1.5 years on average. Although the metabolism of hyaluronic acid is ongoing, its absorption rate will gradually accelerate at a later stage. Therefore, in order to maintain the best condition, I personally recommend supplemental injections 1 year after the first injection for the following 3 reasons: First, to slow down the metabolic rate of hyaluronic acid. The research and clinical experience of hyaluronic acid fillers tell us that supplemental injections when hyaluronic acid is not completely metabolized can delay its metabolism; second, to save money. When supplementary injections are given, the amount of injected dose will be significantly reduced compared with the first time, so the cost of consumables will also be reduced; thirdly, a lot of studies have confirmed that the metabolic rate of hyaluronic acid is overall low in the first year after the first injection, and the metabolic rate is gradually accelerated after one year, so it is most appropriate to inject at that point of time. Do I need to be circumcised for hyaluronic acid injection? Circumcision is a very common phenomenon. If the circumcision is obvious, after the hyaluronic acid injection (especially when the larger dose is >15ml), because the foreskin tissue is very loose, the hyaluronic acid is very easy to move to the foreskin, which has a greater impact on the effect of enlargement, resulting in a lower satisfaction of the treatment. Can circumcision and hyaluronic acid injection be performed at the same time? In principle, I do not recommend that circumcision and hyaluronic acid injections be performed at the same time. This is because both circumcision and hyaluronic acid injections are invasive operations, and performing both procedures at the same time not only increases the risk of post-operative infection, but may also cause a longer post-operative recovery period, which is really a desire for speed. Therefore, it is recommended that circumcision be performed first and then hyaluronic acid injections be performed about one month after the surgery.