Premature ejaculation with deficiency of yin and yang should be treated with drugs that nourish yin and strengthen yang, such as Gui Fu Di Huang Wan and Liu Wei Di Huang Wan, by a Chinese medicine practitioner after diagnosis. Yin and yang deficiency can be seen in hot flashes (a burst of fever), night sweats (abnormal sweating after going to sleep, but sweating stops after waking up), zygomatic flushing (reddish color of the cheekbones on both sides of the face) and other symptoms of yin deficiency, as well as symptoms of yang deficiency, such as fear of cold, coldness of the limbs, and loose stools (thin and unshaped feces). Therefore, clinical medication should not only nourish yin and nourish the kidneys, but also take into account warming the kidneys and strengthening yang (warming and nourishing yang qi in the kidneys), which can be done by taking Six-flavored Dihuang Pills together with Gui Fu Dihuang Pills. According to the different degrees of yin and yang deficiency, the combination of drugs should also be adjusted. If the yang deficiency is dominant, then Gui Fu Di Huang Wan should be the mainstay, or Jin Gui Ren Qi Wan should be used instead. If the yin deficiency is dominant, then Liu Wei Di Huang Wan should be the mainstay, or Zhi Bai Di Huang Wan should be used instead. Yin and Yang deficiency premature ejaculation should follow the doctor’s instructions to standardize the use of medication treatment, not unauthorized use of medication.