What is ca125? CA125 is a tumor marker with a normal range of less than 35 U/mL. The test is performed by drawing peripheral venous blood and does not require fasting. However, it is important to avoid menstruation and pregnancy during the test. Ca125 is most commonly found in the serum of patients with epithelial ovarian tumors, especially plasma tumors, and has a high diagnostic sensitivity but a low specificity. It is more sensitive for diagnosis but less specific. Early cases are not too often elevated, but in 90% of patients ca125 is associated with disease progression. Therefore, it is mostly used for disease detection and efficacy assessment. In the diagnosis of the disease, CA125 can only be used as one of the auxiliary diagnostic methods. This means that the value of ca125 can only be used in conjunction with other tests to allow the doctor to make a judgment, just as a reference. In which diseases can it be elevated? Elevated CA125 can occur in malignant tumors, such as ovarian cancer, endometrial cancer, fallopian tube cancer, breast cancer, bowel cancer and other diseases. If there is a significant increase in CA125 value, especially if it exceeds 200 U/mL or even greater than 1000 U/mL, in this case it is highly suspected whether there is a malignant tumor, and if in this very high case the possibility of malignant tumor must be excluded. However, an elevated CA125 value does not necessarily mean that you are suffering from cancer, so if you find this situation, you must not panic and go to the hospital for the corresponding examination to confirm the diagnosis. Elevated CA125 can also occur in patients with adenomyosis, fibroids, endometriosis, pelvic inflammatory disease or ovarian cysts, chocolate cysts and the like. These are all benign diseases and are not life threatening. Therefore, for such patients, they can be treated separately according to the disease. When the disease is well, CA125 will also return to normal. The relationship between CA125 and adenomyosis? Adenomyosis is a benign tumor and most of the patients with adenomyosis have elevated ca125, and some of them can reach 200U/mL or even thousands. Does it mean that the higher the ca125 value, the more severe the adenomyosis? There is no definite answer to this question. Some patients with adenomyosis have ca125 values that are just a little higher than normal, while others have ca125 values that are as high as 200 or more, but those with ca125 values that are as high as 200 or more do not have very obvious symptoms. For patients with adenomyosis, if there are no accompanying ovarian tumors on the body, then high CA125 is usually just caused by simple adenomyosis, so it is usually not malignant, CA125 is just a reference value. When will adenomyosis patients ca125 value will return to normal? 1, after the injection, some patients will return to normal. Adenomyosis patients will have CA125 return to normal after leucovorin, daphylline and other injections. Of course the uterus will also shrink appropriately. But this is not a sign of adenomyosis cure. It just means temporary control. Just like one patient who is 35 years old, started to have severe menstrual pain at the age of 20, and was diagnosed with adenomyosis in ’02. She started to take Chinese medicine in ’03. In 12 years she continued to seek medical help, her doctor prescribed her Dalfin, and during five months, no menstruation and no stomach pain, her uterus returned to normal size from 8 weeks, and CA125 returned to normal from 135. But two months after her injection her hands started to develop morning stiffness, so she stopped the medication. On the Mannish, during which she took mifepristone for half a month, the pain was relieved after normal menstruation. 5 months after the IUD, her menstrual flow suddenly increased, but it did not hurt, so she did not care, and in the next month she started to have menstrual pain again! Three days, anti-inflammatory pain tethering. I went to the doctor again and the ultrasound showed that the ring was gone and the uterus was enlarged! Then still had menstrual cramps. Even though the injection can make the uterus shrink and the ca125 return to normal, I still don’t recommend this method because it doesn’t really solve the adenomyosis problem, it’s only temporary and it tends to rebound. Of course if you are trying to have a baby and get shots, you can also consider it. 2, do uterine preservation surgery uterine preservation surgery, the premise of preserving the complete form of the patient’s uterus to the patient’s myometrium within the adenomyosis lesions to remove, uterine preservation surgery is different from the simple uterus everything up, is a relatively high demand for the team of surgeons, but also a very beneficial operation for adenomyosis patients. It relieves the patient’s pain while preserving the uterus, ovaries and other important organs. After the uterine preservation surgery, adenomyosis patients will not suffer from menstrual pain, their menstrual flow will decrease, their uterus will return to normal size, they will resume their normal working life, and the anemia caused by heavy menstrual flow will slowly improve until it returns to normal. the Ca125 will also return to normal value.