Chest tightness and wheezing during sleep is seen in low blood pressure, bradycardia, heart failure, bronchial asthma, etc. Different medications can be taken to treat different causes. 1. Low blood pressure leads to insufficient blood supply to the brain, the patient will appear at night chest tightness and wheezing. If you are taking antihypertensive drugs during this period, you should stop taking them or reduce their dosage. If the situation is critical, you should use norepinephrine to raise the blood pressure and actively consult a doctor for treatment. 2. In bradycardia, the vagus nerve is excited at night and the heart rate is slowed down, which may cause arrhythmia and chest tightness. Drugs such as atropine can be applied for treatment. 3. People with heart failure will have dyspnea at night, taking diuretics such as furosemide and positive inotropic drugs such as digitalis to relieve the symptoms. 4. Bronchial asthma is prone to attacks at night and symptoms of chest tightness and breathlessness, which need to take inhaled glucocorticoids or aminophylline to relieve symptoms. If you experience chest tightness and wheezing at night, it is recommended that you seek medical attention to identify the cause of the problem and actively treat it under the guidance of your doctor.