Disulfiram-like reaction refers to the occurrence of facial flushing, conjunctival congestion, blurred vision, severe pulsating or throbbing headache and dizziness of the blood vessels in the head and neck, nausea, vomiting, sweating, dry mouth, chest pain and chest tightness, shortness of breath, dyspnea, cardiac failure, exhalation failure, acute liver injury, convulsions and even death if alcohol is consumed after the administration of the drug. On examination, there may be a drop in blood pressure, accelerated heart rate (up to 120 beats/min) and normal or partially altered electrocardiogram (e.g., ST-T changes). Its severity is directly proportional to the dose of the drug and the amount of alcohol consumed, the elderly, children, cardiovascular and cerebrovascular disease and ethanol sensitivity is more serious, this reaction usually occurs 15-30 minutes after the use of the drug and alcohol consumption. The drugs that can cause disulfiram reaction are as follows: Cephalosporins: such as cefoperazone, cefoperazone sulbactam, ceftriaxone, cefazolin (Pioneer V), cefradine (Pioneer VI), cefmetazole, cefminox, cephalosporin, cefmetaxime, cefmandole, cefadroxil (Pioneer Ⅳ), cefaclor and so on, which to cefoperazone to the bisulfiram-like reaction of the largest number of reports and the most sensitive, such as Some patients who ate heart chocolate, took patchouli, or even treated the skin with alcohol only had disulfiram-like reactions after use. These cephalosporins in the chemical structure of the common characteristics of its parent nucleus 7 – amino cephalosporanic acid (7-ACA) ring on the 3 position of the methyl sulfur tetrazolium (thiomethyl tetrazolium) substituent, which competes with coenzyme Ⅰ the active center of acetaldehyde dehydrogenase, which can prevent acetaldehyde continue to oxidation, leading to the accumulation of acetaldehyde, which can lead to alcohol withdrawal sulfur-like reaction. The appearance of precordial pain accompanied by electrocardiographic ST-T changes is due to the methylthiotetrazole substituent causing increased sympathetic excitability, resulting in increased heart rate, increased myocardial oxygen consumption, shortening of the myocardial diastolic phase, reduced coronary artery perfusion pressure, resulting in reduced perfusion flow. (Cefotaxime, ceftazidime, cefsulodine, cefazoxime, cefixime, because it does not contain methylthiotetrazole group, drinking alcohol during the application will not cause a disulfiram-like reaction.) Nitroimidazoles: e.g., metronidazole (methotrexate), tinidazole, ornidazole, and teknidazole. Other antimicrobials: e.g. furazolidone (dysentery), furotoxin, chloramphenicol, ketoconazole, griseofulvin, erythromycin succinate, isoniazid. Hypoglycemic drugs: e.g. chlorosulfopropamide, phenelzine, glibenclamide, gliclazide, glipizide, insulin, etc. Other drugs: e.g. warfarin, trifluoperazine, tolazoline, chloral hydrate, etc.