The peak time of ABO hemolytic jaundice in newborns is usually about 3-5 days after the jaundice. This condition is usually caused by a blood group discrepancy between the mother and the fetus, which can slowly disappear and resolve within half a month. If there are no specific symptoms, the condition can be observed. If the symptoms are mild, no special treatment is needed. However, if the jaundice is severe, we should actively consider blood exchange therapy or blue light irradiation treatment, which can be carried out in the incubator for about 1-2 weeks. The patient’s bilirubin will slowly decrease through active blue light exposure. If the patient’s bilirubin is more elevated, it may cause bilirubin encephalopathy, also known as kernicterus, which may further affect the child’s intelligence. Therefore, for jaundice caused by ABO hemolysis, active treatment should be considered as soon as possible, and blue light irradiation treatment and liver protection treatment should be performed if necessary, and the child can also be given Gardenia Yellow granules to actively reduce jaundice.