Cold and Fever Granules are composed of Radix et Rhizoma Polygonati, Radix Piperitae, Radix Bupleurum, Radix Bupleurum, Radix Perillae, Radix Puerariae, Radix Platycodon, Radix Angelicae, Radix Angelicae Sinensis, Radix Rehmanniae. Cold and fever granules are safe and no side effects caused by this drug have been found. By analyzing the main ingredients of cold and fever granules, the possible side effects of the drug are considered to be skin allergy, hypoglycemia, central nervous system reactions (psychosis), respiratory system reactions (pulmonary edema, lung injury, lung cancer, and asthma), digestive system reactions (irritation as well as inflammation), cardiovascular system reactions, and liver cirrhosis. A case of recurrent hypoglycemia caused by the heavy use of E. oryzae in a Chinese herbal formula was reported in the literature, which concluded that in addition to its expectorant and cough suppressant effects, its water or alcoholic extract, when taken internally, could cause a decrease in blood glucose in rabbits. This literature emphasizes that Eustoma can induce hypoglycemia, which arises not only from a slightly higher dosage but also from individual differences. It should be taken into account. The safety of menthol, also known as menthol, a saturated cyclic terpene alcohol found in peppermint and euphorbia essential oils, has been studied in the literature. The literature concluded that menthol was considered non-toxic and harmless in the prescribed dose range (0-012 mg/kg/day) when it was widely used as an aromatic agent and flavoring, but with the widespread and extensive use of its adverse reactions have occurred, the literature also summarized the adverse reactions of menthol as allergic reactions, central nervous system reactions (psychosis), respiratory reactions (pulmonary edema, lung injury, lung cancer, and asthma), digestive reactions, and lung cancer. The literature also summarizes the adverse reactions of menthol as allergic reactions, central nervous system reactions (psychosis), respiratory system reactions (pulmonary edema, lung injury, lung cancer, and asthma), digestive system reactions (irritation and inflammation), cardiovascular system reactions, and liver cirrhosis. Also, since the amount of peppermint in the ingredients of cold and fever granules is not specified in the drug’s instructions, it is debatable whether the drug may cause the above-mentioned side effects.