The patient, female, 31 years old, was treated with anti-inflammatory fluids for more than 10 days in an outside hospital for clear watery runny nose, fever of 39℃, and headache, and her symptoms did not improve. Could it be that this patient has a rare “spontaneous cerebrospinal fluid rhinorrhea”? Glucose was collected from the left nasal cavity for quantitative glucose testing, and the result was 4.3 mmol/L (greater than 1.67 mmol/L), which was combined with CT and other imaging tests to diagnose “spontaneous cerebrospinal fluid rhinorrhea”. On the morning of July 2, 2009, under general anesthesia, Dr. Ma performed a transnasal approach to repair the cerebrospinal fluid leak. During the operation, Director Ma found a 6×8 mm skull base bone defect on the medial side of the septum, and found two leaks with cerebrospinal fluid spillage, scraped the leaks, cut the ipsilateral part of the middle turbinate to seal the leaks, fixed with bioprotein glue, covered with gelatin sponge, and filled the operation cavity with iodoform gauze. Under the careful treatment and care of the medical staff, the patient passed the infection hurdle peacefully, and all the nasal stuffing was withdrawn 14 days after the operation. The patient was discharged from the hospital as scheduled, and when he came back for a review, he was happy to take a photo with the medical and nursing staff of the department.