Laboratory tests for genetic metabolic disease screening include routine blood and urine analysis, biochemical tests such as blood glucose, blood gas analysis, liver function, cardiac enzyme profiles, and bilirubin, blood ammonia, lactate, ketone bodies, pyruvate, creatinine, urea, electrolytes, calcium, and phosphorus measurements, which can help to make a preliminary judgment or narrow down the diagnosis of inherited metabolic diseases. Inherited metabolic diseases include phenylketonuria, congenital hypothyroidism, G-6-PD deficiency, etc. Consultation with a doctor is recommended. 1. Phenylketonuria: autosomal recessive inheritance, which can lead to mental retardation and motor disorders in children. There are no special manifestations in the neonatal period, and some of them may have feeding difficulties and vomiting, and newborn screening is an effective method for early diagnosis. 2. Congenital hypothyroidism: Newborns with congenital hypothyroidism may be asymptomatic or have only suspected symptoms, such as low body weight, slow heart rate, hypomobility, prolonged physiologic jaundice, feeding difficulties, and intractable constipation. Symptoms are atypical and screening is an effective method for early diagnosis. 3. G-6-PD deficiency: Clinical manifestations in newborns are hemolytic anemia and hyperindirect bilirubinemia, which may lead to bilirubin encephalopathy in severe cases. At present, there are many kinds of genetic metabolic diseases, the overall incidence rate is high, and the clinical manifestations are atypical and easy to be ignored. It is recommended that newborns complete genetic metabolic disease screening in regular hospitals to avoid delaying the condition.