Pantoprazole is relatively safe overall, but taking pantoprazole for more than 3 years may produce adverse reactions such as causing dysbiosis, pseudomembranous enteritis, gastric polyps, and patients occasionally experience gastrointestinal symptoms such as epigastric pain, diarrhea, constipation or bloating. A small number of patients may experience nausea or occasionally cause allergic skin reactions such as pruritus and rash, and may also cause neurological symptoms manifested as less common dizziness and visual disturbances. Pantoprazole is usually used to treat active peptic ulcers, reflux esophagitis, and chronic gastritis, and is now also used in antiplatelet and hormone therapy to prevent mucosal damage. However, pantoprazole should not be taken for a long time. The course of pantoprazole is usually 2-4 weeks for diseases such as erosive gastritis and duodenal ulcer, and 4-8 weeks for gastric ulcer, reflux gastritis, and reflux esophagitis. The disease should be regularly observed for remission, and if long-term medication is indeed required, liver and kidney function should be reviewed regularly. In addition, the drug inhibits the secretion of gastric acid for a strong and long time, so it should not be applied with other antacids or acid suppressants, and in order to prevent excessive acid suppression, it is also not recommended to apply large doses for a long time, otherwise it may increase the chance of cardiac arrhythmia, increased transaminases, changes in renal function and decreased granulocytes.