The redness and swelling of red fire ant bites is an insect bite reaction, and the patient may be treated with medications such as glyburide lotion and cetirizine as prescribed by the doctor. Localized redness and swelling after being bitten by red fire ants may be an insect bite reaction, which may be accompanied by other symptoms such as erythema, blisters, and itchy skin. Clinically, it is recommended to wash the bitten area with soapy or running water, apply ice packs and glycerite lotion to relieve the localized redness and swelling. Some red fire ant bites need to be treated with antihistamines, such as cetirizine and loratadine. Severe cases usually need to be treated with glucocorticosteroids such as methylprednisolone and hydrocortisone as prescribed by the doctor. If the patient has obvious localized muscle spasm, the patient can be treated with drugs such as 10% calcium gluconate and diazepam as prescribed by the doctor. It is recommended that people bitten by red fire ants and swollen as soon as possible to seek medical treatment, but also should follow the doctor’s instructions to use medication, do not use their own drugs or prescriptions.