Cephalosporin antibiotics are currently a class of antibiotics that are very widely used in clinical practice and have the advantages of a broad antibacterial spectrum, strong antibacterial activity and low toxic side effects. It should be especially emphasized that if you drink alcohol during the use of cephalosporin antibiotics or within 2 weeks of stopping the drug, you will experience abdominal pain, nausea, vomiting, headache, dizziness, chest tightness, flushing, blurred vision, and even blood pressure drop, respiratory difficulty, confusion, heart failure, convulsions, brain hemorrhage, myocardial and liver and kidney damage, which are likely to be caused by the reaction between cephalosporin and alcohol “disulfiram-like reaction”. It is more serious in children, elderly people and allergic people, and can even lead to death if resuscitation is not timely. Under normal circumstances, alcohol is converted into acetaldehyde in the liver, and acetaldehyde is converted into acetic acid under the action of acetaldehyde dehydrogenase, and then into water and carbon dioxide and discharged out of the body. Cephalosporin antibiotics can inhibit acetaldehyde dehydrogenase in the body, so that alcohol cannot be discharged after being converted into acetaldehyde in the body, resulting in acetaldehyde poisoning and a very unpleasant drunkenness-like reaction. A very small amount of alcohol mixed with cephalosporin can lead to alcohol poisoning, which can cause heart failure or even death in serious cases. Now that cephalosporin antibiotics are available both orally and by infusion, we are advised not to drink alcohol during illness. In addition to alcohol, alcohol should also be prohibited during the administration of tofu milk, patchouli and some hypoglycemic drugs. Alcohol should generally be consumed 2 weeks after stopping the medication.