Metformin is irritating to the stomach and some patients may experience nausea and vomiting after taking it. If the above symptoms occur, metformin can be taken after or during meals instead. Secondly, the above symptoms can be relieved by reducing the dose and number of times of each dose, but if the total amount of metformin use is reduced leading to an increase in blood sugar, it needs to be combined with other hypoglycemic drugs to control blood sugar. In addition, some patients can be treated with metformin extended-release tablets or metformin enteric-coated tablets instead, and the stomach irritation will be reduced. Metformin causes nausea and vomiting and other symptoms are very common adverse drug reactions, if the reaction is severe and intolerable, it is recommended to adjust to other glucose-lowering drugs for treatment according to the condition.