1, toothache: toothache is mostly caused by dental disease, the pain is persistent, mostly limited to a certain tooth or a few teeth gingival, localized with tooth percussion pain and pathogenic lesions (dental caries, periodontitis, etc.), X-ray and dental examination can confirm the diagnosis. Trigeminal neuralgia is often misdiagnosed as toothache, and often the healthy teeth are extracted, or even all the teeth are extracted but still ineffective, which should be noted. 2.Glottopharyngeal neuralgia: it is easy to be confused with trigeminal nerve branch 3 pain, and the sites of glottopharyngeal neuralgia are different, such as soft palate, tonsils, pharyngeal tongue wall, tongue root and external auditory canal. The pain is induced by swallowing action. The pain can disappear after spraying the pharyngeal area with 1% pantocaine or cocaine, etc. Ni Duanyu, Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University 3. Trigeminal neuritis: short history, pain is persistent, sensory hypersensitivity or hyperalgesia in the trigeminal nerve distribution area, may be accompanied by mastication and other motor disorders, and there is obvious pressure pain in the involved branches of the trigeminal nerve. 4.Temporomandibular arthritis: Pain is limited to the temporomandibular joint cavity, persistent, with pressure pain in the joint area and joint movement disorders. 5.Migraine: The pain area is beyond the range of trigeminal nerve, and there are mostly visual aura before the attack, such as blurred vision, dark spots, etc., which may be accompanied by vomiting. The pain is persistent and long, often half a day to 1-2 days. 6, paranasal sinusitis: such as frontal sinusitis, maxillary sinusitis, etc., for limited persistent pain, may have fever, nasal congestion, thick runny nose and local pressure pain, etc. 7, cerebellopontine horn tumor: the pain attack may be the same as trigeminal neuralgia or atypical, but mostly seen in young people under 30 years old, with hyperalgesia in the trigeminal distribution area, and may gradually produce other symptoms and signs in the cerebellopontine horn of the cerebellum. X ray, CT intracranial scan and MRI can help to confirm the diagnosis. 8.Tumor invasion of skull base: most common is nasopharyngeal carcinoma, often accompanied by epistaxis and nasal congestion, which can invade most cerebral nerves and enlarged cervical lymph nodes, and the diagnosis can be confirmed by nasopharyngeal examination, biopsy, skull base X-ray, CT and MRI. 9, glaucoma: acute attack of unilateral glaucoma is easily misdiagnosed as trigeminal nerve branch 1 pain, glaucoma is persistent pain, does not radiate, may have vomiting, accompanied by congestion of the conjunctiva, shallow anterior chamber and increased intraocular pressure, etc. 10.Tumor of trigeminal nerve hemianopsia: ganglion cell tumor, chordoma, meningioma of McDonald’s fossa, etc. There may be persistent pain, and the patient has obvious trigeminal nerve sensory and motor disorders. There may be bone destruction and other changes on skull base X-ray. 11.Atypical facial pain: Mostly seen in young people, the pain is beyond the trigeminal nerve and can extend to behind the ear, head, occipital neck, and even shoulder. The pain can be persistent, up to several hours, not related to the movement, not afraid of touch, can be bilateral pain, and can be heavier at night.