For premature ejaculation caused by heart-kidney disharmony (heart fire, kidney yin deficiency, dysfunction of the physiological functions of the heart and kidneys), Chinese medicine usually chooses medications that nourish yin and lower fire (nourish yin essence and lower the fire), and communicate with the heart and kidneys (heart fire descends, kidney water rises, and mutual control), such as Zhi Bai Di Huang Wan and Jiaotai Pill. 1. Zhi Bai Di Huang Wan: this medicine can play a role in nourishing Yin and lowering fire in the clinic, which includes Di Huang, Yam, Zhi Mu, Huang Bai and so on. It is mainly used for the symptoms of kidney yin deficiency and exuberant fire, such as lumbar and knee soreness and weakness, night sweating (abnormal sweating after going to sleep, but sweating stops after waking up), dry mouth and tongue, and heartburn and insomnia. 2. Jiaotai Pill: This medicine can transport the heart and kidney (heart fire descends, kidney water rises, mutual control), clear the heart and lower the fire, and also treat premature ejaculation caused by heart-kidney disharmony, with Huanglian and Cinnamon as the main medicines. The adverse effects of the above medications are not clear, so it is recommended to consult a doctor before using the medication.