Pregnancy begins with fertilization. Fertilization is the production of half of the human chromosomes from each male and female germ cell to form a new individual. If there is a chromosomal abnormality on either side, there is a theoretical possibility that the new individual will have an abnormal embryo and miscarriage will occur, or conception will be impossible. Is it possible to have a child with a chromosomal abnormality? Chromosomal abnormalities can cause infertility and difficulty in conceiving, and can also increase the chance of spontaneous abortion and fetal abortion if the pregnancy is due to chromosomal abnormalities. Chromosomal abnormalities cannot be treated, but they are not absolutely 100% unacceptable. The clinical significance of chromosomal polymorphism is not yet clear, and the impact on the child cannot be determined for the time being, so the child can be born normally. In the case of Y chromosome microdeletion affecting the male partner’s semen, in vitro fertilization is also possible if semen is available, but if it is a boy, he may inherit the father’s chromosomes and have the same situation as the father; however, if there is no sperm and sperm production is impaired, donor sperm is needed to assist conception. If the female partner has X chromosome deletion, there is often decreased ovarian function, and if there are follicles, it is still possible to obtain offspring from blood relatives by IVF; if the female chromosome has one more chromosome that can split into normal and abnormal chromosomes, and the normal chromosome is fertilized with sperm, it is a normal fetus.
In conclusion, couples with chromosomal abnormalities must have a chromosomal examination before preparing for childbirth, and then go to a genetic counseling clinic for specific analysis to conceive a healthy baby with the help of a doctor.