Oculocutaneous nevus, also known as Ota nevus, is the original Japanese name for the brownish-blue spot on the palate of the eye. Oculocutaneous nevus is not uncommon in China. It usually appears at birth or after birth, and tends to worsen in youth, and some occur in youth, often with family history, and is inherited by autosomal dominant. The lesions are patches of light blue, brownish blue or greenish black spots, distributed on one side of the face, sometimes bilaterally, most commonly on the forehead, temporal area, orbits, nose and cheekbones. Half of the patients have brown spots on the sclera of the eye, especially on one side, and the conjunctiva may also have pigmentation. The disease is benign with occasional nodules or bullae associated with cyanotic nevi and occasional complications of malignant melanoma. There are also scattered pigmented spots occurring on the zygomatic area, 1 to 3 mm in diameter, gray-brown, gray-blue or dark brown, symmetrically distributed, not involving the eyes and palate. It is called zygomatic brown-cyanotic nevus. This disease is similar to speckled melasma, but the former has deeper pigmentation sites and is often gray or blue in color. The IL nevus has similar lesions to this disease, but occurs in the shoulder, clavicular region or deltoid area innervated by the superior clavicular nerve and lateral branches of the brachiocephalic nerve. Oculocutaneous nevus and nevus of IL can coexist, and both cannot fade away spontaneously. Currently, the application of 1064 nm wavelength Q-modulated laser treatment can achieve satisfactory results.