Sudden death during infusion is a common phenomenon in medical practice. In the doctor’s view, almost every day there are patients who die during the infusion process, all critical patients have to be infused, and death in the infusion is too rare; while in the patient’s view, the ability to infusion, that the patient can still be saved, before the infusion alive, the infusion suddenly cold yin and yang, unacceptable, from the analysis of the time relationship alone, the infusion must be the culprit of death. It is understandable that the doctor-patient disagreement and the conflict is intense. The most common cause is the natural progression of the disease, which may account for more than 90% of deaths from infusions. The reason is self-explanatory: most patients spend time in the hospital at the end of their disease, and end-stage means that all physiological and therapeutic needs are obtained only through infusions, so death by infusion is a natural outcome. The only way to reduce deaths in infusion is to reduce infusions. Such deaths do not create legal liability. The second cause is drug allergic death. This includes two causes, one is the drug’s own chemical composition causing the body to be allergic, and the other is the drug is not allergic but the infused fluid contains impurities that can cause allergy. For drug allergy, most of the legal liability in two links, one is the skin test is not skin test, such as penicillin; second is negligent prevention and response, such as cephalosporin drugs do not require skin test, but if negligent foresight and in the occurrence of allergies after the failure to take effective anti-allergy measures, can generate legal liability. For allergies caused by impurities other than drugs, the responsibility is mostly borne by the pharmaceutical companies, but it is more difficult to legally determine that the impurities cause allergies. According to the relevant literature, impurity allergy accounts for the majority of infusion reactions in China, which is a social problem that can be solved in a day. The third reason is the side effects of drugs. Toxic side effects of drugs are different from allergic reactions that occur under normal drug use, and are dose-related, but not related to the purpose of treatment, and can cause functional or organic damage to the body, including toxic reactions and side effects, such as hepatotoxicity of He Shou Wu, nephrotoxicity of Guan Mu Tong, sleepiness of Contec, dry stools and other side effects. There are not many cases of death caused by toxic side effects of drugs in infusion, because it takes time for any toxic side effects to occur, and it is difficult to cause immediate fatal causes. However, certain drugs that can cause cardiovascular side effects may lead to death during infusion. The author has encountered cases of death during infusion of lincomycin and prostaglandin, and the identification constitutes medical damage, the reason is that these two types of drugs, both of which have toxic side effects that cause hypotension and decreased oxygen saturation, may lead to death during infusion, but the doctor used the drug in violation of the relevant norms. However, toxic side effects, by their nature, are problems in drug development, which are difficult for doctors to foresee and prevent, so it is quite difficult to hold them legally liable. The fourth reason is the violation of drug administration norms. For example, if the route of administration is changed from intravenous drip to intravenous push, or from oral to intravenous drip; or if the principle of contraindications to the use of drugs is violated, such as those with severe cardiopulmonary insufficiency or cardiac arrhythmia, but the use of drugs that can cause a drop in blood pressure and aggravate cardiac arrhythmia is prohibited, it may lead to death during the infusion process. The fifth reason is the infusion of the wrong medication. This includes checking the wrong doctor’s orders or simply mistaking the patient, infusing drug A with drug B, or infusing a drug given to patient A with patient B. The most frequent is a blood type verification error, such as transfusion of blood type A into blood type B. Other more rare causes include inadequate infusion techniques, such as air embolism caused by air not being evacuated before infusion; needle breakage during intravenous placement, etc. Most of the above causes of death in infusion can be clarified by the fact of infusion, the objective performance of the patient during life, the detection of uninfused drugs, etc. If they are not clear, they can also be clarified by autopsy. Unfortunately, when people lose trust, reason is difficult to be the solution to the lawsuit, so violence is repeatedly staged. The violence will only create more violence.