As we all know, many diseases have a very obvious initial effect during the treatment process, but over time, despite no change in the treatment plan, the effect is getting worse and worse, or even ineffective, which is collectively known as “drug resistance” in medicine, and the people often say that they have adapted to the drug. Drug resistance is a common and effective means for human beings to fight against diseases or pathogens in the process of treating diseases (pathogens), and is one of the common reasons for human defeat. Drug resistance is a common phenomenon in the treatment of almost all diseases, especially in the treatment of some chronic diseases that require long-term medication; most commonly in antibiotic therapy, hepatitis B antiviral therapy, tumor chemotherapy, and the treatment of immune diseases. How do diseases or pathogenic bacteria develop drug resistance? When does resistance develop? Although their respective specific ways are different and varied, current research shows that the following three ways are more common: 1, mutation: pathogenic bacteria will take their own mutation to survive and reproduce in the process of fighting with humans, such as hepatitis B patients treated with lamivudine, there will be a mutation of hepatitis B virus such as YMDD and other drug resistance. 2, by drug-induced production of some special enzymes to break down the drug, so that the drug fails, especially in the antimicrobial treatment of bacterial infections, bacteria will produce some hydrolytic enzymes to break down the corresponding antimicrobial agents to make them fail, thus, the production of new drug-resistant strains, so that bacteria can survive. 3. Gene mutations produce special proteins to change the target of drug action, so that the drug loses its target, or “pumps” the drug that enters the cell out of the cell, thus making the drug ineffective. This phenomenon often occurs in tumor chemotherapy, which makes it difficult for human society to overcome tumor completely. How to face the problem of drug resistance as a patient? The key is to treat it correctly, to realize that drug resistance is a way for the disease to fight against human beings, and secondly, to reflect your situation to your treating doctor in time to get his professional treatment advice, and not to ignore or ask questions, or even stop the drug by yourself, or increase the dose without authorization, all these practices are undesirable and will only aggravate the disease, bring adverse consequences and even endanger the life. As a professional, the treating doctor will take into account the specific situation of the patient at that time, make a judgment after further examination, and take some new effective measures (including changing the drug, combining drugs, adjusting the method of medication, etc.). Lastly, I would like to emphasize one point in particular – do not buy drugs from pharmacies on your own, as this may not only fail to cure the disease, but also delay the best time for treatment, and even accelerate the development of drug resistance, which in effect increases the power of the disease against human beings and makes certain diseases more difficult to treat.