Trigeminal neuralgia is a sudden onset of severe pain in the trigeminal nerve distribution area, also known as “painful spasm” because of the intensity of the pain. Drug therapy for trigeminal nerve is the most commonly used basic treatment and the first choice for this disease. The indications for drug therapy are mainly for patients with initial onset of the disease, but also for patients who are too old or have other serious organ systemic diseases that are not suitable for surgery, or who cannot tolerate surgery, as an adjunct to other treatment methods. The main antiepileptic drugs: such as carbamazepine, oxcarbazepine, phenytoin sodium, clonazepam, sodium valproate, gabapentin, lamotrigine, topiramate, etc. Currently, carbamazepine is considered to be the most effective drug for trigeminal neuralgia, but long-term application can occur bone marrow suppression and liver function damage, which should be observed. 2.Antitussive drugs: beclofen is a muscle relaxant and antitussive drug, which can also be used in the treatment of trigeminal neuralgia. It can be used alone when carbamazepine or phenytoin sodium is ineffective, but also in combination to enhance the therapeutic effect. 3.Dopamine receptor blocker: Pimozide is a dopamine receptor blocker, mainly used in antipsychotic treatment, and can be tried when other drug treatments are ineffective. 4.Nutritional drugs: In order to promote nerve repair, B vitamins, such as vitamin B1, B6 and B12, can be given for treatment. Large doses of vitamin B12 not only have the effect of promoting nerve repair, but also have a certain analgesic effect. However, it should be noted that vitamin B12 should be avoided for long-term administration or injection to avoid poisoning. Therefore, it should be taken under the guidance of a professional doctor’s advice for the medication. When medication or obvious side effects occur, surgical treatment should be considered.