There is no such thing as a nemesis drug for cramps. Cramps may be related to calcium deficiency, nerve damage, muscle tension, poor blood circulation, osteoporosis and other factors, you can take oral calcium supplements, nutritive nerve medication, muscle relaxants, medication for unblocking the meridians, bisphosphonates and so on. 1. Calcium supplements: When the body lacks calcium and combines with osteoporosis, cramps are easy to appear, and oral calcium supplements, such as calcium lactate and calcium carbonate, are needed. 2. Nutritional nerve drugs: nerve damage is also prone to cramps, you can take oral nerve drugs, such as methylcobalamin tablets, vitamin B1 and so on. 3. Muscle relaxants: patients with severe local muscle tension symptoms of cramps, you can take oral ethylpiperidone, chlorzoxazone, etc. to relieve muscle tension symptoms. 4. Meridian relief drugs: when the patient’s hands and feet have poor blood circulation leading to cramps, you can take oral medicines such as Daxuoluo Pills to promote blood circulation. 5. Bisphosphonates: patients with severe osteoporosis and cramps can use bisphosphonates such as alendronate and neridronate. Cramps should go to the regular hospital in time, and be instructed by the doctor to use the medicine.