Some patients with minor triplets can turn negative, while others cannot. Whether they can turn negative depends on whether the hepatitis B virus is an acute infection or a chronic one. The chronic infection also depends on the viral load, the number of HBV-DNA, HBsAg quantification, and the type of antiviral drugs chosen and their own immunity and other factors. 1, acute hepatitis B virus infection: if adolescents and adults are infected, about 90-95 percent can turn negative, mainly through their own immunity to clear the virus, 70-75 percent of infant and early childhood infections can turn negative. The majority of perinatal infections will become chronic, and only 10% can be turned negative; 2. Chronic hepatitis B virus infection: only a small number of people can be turned negative, and most cannot be turned negative. For those with low HBsAg titers, low HBV-DNA levels, and 5-10 times higher transaminase levels, there is hope for conversion based on oral antiviral drugs plus long-acting interferon antiviral therapy. Patients who do not achieve conversion after the above treatment will also need long-term oral antiviral therapy and regular review at the hospital to prevent changes in immunity that could cause liver damage.