Why is advanced pregnancy a priority group for prenatal screening and prenatal diagnosis? With the liberalization of the national second child policy, many women of advanced age have jumped at the chance. However, there are a lot of difficulties in the process of conceiving a second child, just like playing a game to break through the levels, do you understand these levels and are you ready to deal with them? The first hurdle is whether or not you can get pregnant. After the age of 35, the female body estrogen and progesterone levels slowly decline, especially after the age of 38, its hormone levels are diving-like plummet. Moreover, the quality of semen of men at this age also decreases gradually, resulting in a reduced chance of pregnancy. Therefore, it is important to let nature take its course and not to force the pregnancy. The second hurdle is whether the embryo will survive or not. The low estrogen level of older pregnant women leads to the thinning of the endometrium, and the lower progesterone leads to poor embryonic development, which significantly increases the chance of miscarriage and embryonic arrest. Therefore, after conception, you should be checked as early as possible to know the condition of the embryo. The third barrier is the high incidence of malformed babies. After conception of an advanced pregnant woman, the fertilized egg is prone to chromosomal mutations during division, and the chance of having a child with congenital defects such as Down’s syndrome, which is untreatable, is significantly higher. Therefore, after 12 weeks, it is important to do chorionic villus aspiration or non-invasive DNA testing to rule out any chromosomal abnormalities in the fetus. 21 weeks for systemic ultrasound, 24 weeks for 4D ultrasound and 28 weeks for fetal heart ultrasound to fully understand whether the fetus has abnormalities in various systems. The fourth hurdle is that there are many complications. The chances of gestational hypertension and gestational diabetes in the middle and late stages of pregnancy are significantly higher than those of young pregnant women, which can easily cause harm to the mother and child. Some mothers even have to be forced to terminate their pregnancy. In addition, pregnant women who had a previous cesarean delivery are prone to placenta praevia when they get pregnant again, which is medically known as “dangerous placenta praevia”. The hurdles are many! Therefore, it is important to strengthen the number of maternity examinations and communicate fully with the doctor to achieve early detection and early treatment. The fifth hurdle is the delivery hurdle. The sit bones, pubic bone, and skeleton of senior pregnant women have basically ossified and the ligaments are tougher, forming a fixed pelvic cavity. Therefore, advanced maternal age is most likely to have prolonged or difficult labor, and the cesarean section rate is relatively higher, which is a great challenge for pregnant women and fetuses. The sixth barrier, bleeding barrier. The oldest mothers, whether natural birth or cesarean delivery, are prone to postpartum hemorrhage, amniotic fluid embolism and other life-threatening conditions due to the decline in the functions of the body and the reduced contractility of the uterine muscle. The first thing that you need to do is to get a good idea of what you are getting into. The seventh level, postpartum recovery level. The first thing you need to do is to get a good idea of what you are getting into. Senior mothers, these hurdles of giving birth to a second child, if you fully understand and confidently decide to sprint, then, please choose a professional obstetrician to accompany you through the hurdles and escort you!