Pituitary adenoma is one of the common tumors of the nervous system, and its incidence occupies the third place among neurological tumors, accounting for about 10%, with a population incidence of 7.5-15 per 100,000, which has been gradually increasing in recent years. Pituitary adenoma is a neuroendocrine tumor with complex and diverse clinical manifestations, and the development trend of tumor cells itself varies, which brings certain difficulties to the diagnosis and rational treatment of clinical patients. Since pituitary adenoma often occurs in young adults, it seriously affects patients’ growth and development, working life and reproductive function, and if improperly diagnosed and treated, it can cause great impact on patients, families and society. How to avoid misdiagnosis and mistreatment of pituitary adenoma? Most pituitary adenoma patients do not need treatment The incidence of pituitary adenoma is very high. Figuratively speaking, out of 100 people walking on the street, there may be a few with pituitary adenoma. Nowadays, there is a misconception among some patients and even doctors that pituitary adenomas require surgery. For example, if a pituitary adenoma is found during a physical examination, some people immediately ask their doctors to remove the hidden problem, and some doctors are forced to blindly operate on patients for various reasons. This is very harmful. This is because many pituitary adenomas do not require surgery. If the tumor does not grow, many people can live with the tumor and still live a good life for the rest of their lives, but once surgery is done, it may have serious consequences. Some pituitary enlargement is a normal physiological proliferation, which may occur especially in adolescence. CT examination may reveal an enlarged pituitary gland, but this is normal and does not require any treatment. However, doctors in some hospitals nowadays often perform Gamma Knife or surgical treatment for people with such conditions. As a result, the original normal state often becomes hypopituitarism after surgery, and a young girl in her 20s becomes like a 60-year-old woman. Instead of solving the problem, the treatment has a great impact on the patient’s future life. In the treatment of pituitary adenoma, the outcome of treatment is the most important from the perspective of evidence-based medicine. Therefore, in recent years, a new concept has been proposed in the medical field, which is to consider the patient as a whole and adopt a comprehensive treatment approach, tailoring treatment to the individual. This concept has broken the past evaluation criteria for surgeons and established new evaluation guidelines. For example, in the past, the evaluation of a surgeon’s good or bad, often look at his ability to remove tumors, especially some difficult tumors, many doctors can not do, he can do down, and can remove very clean, then he is a good surgeon. As for how the patient is after surgery, it is not the main basis to evaluate the doctor. Therefore, such an embarrassing phenomenon often occurs: before the operation, the patient’s limbs can move, after the operation, although the tumor is cut cleanly, but the patient’s limb function is all gone, the tumor is gone, but the person is paralyzed. This is not a rare occurrence, and once accounted for more than 80% of the operated patients. Nowadays, there is a fundamental change in the concept of pituitary adenoma treatment, emphasizing that in the treatment, the patient should be regarded as a whole, and before treatment, we should fully consider what treatment method should be used, how much improvement the patient can have after treatment, and how to make the patient get the best result. After the treatment, we have to look at the overall effect of the patient, for example, whether the symptoms have improved or not, and whether the quality of life has improved or not. This is the sole purpose of treatment and the standard by which a doctor is judged. Minimally invasive approach for pituitary adenoma treatment is effective In the past, to remove the huge tumor in the parasternal and slope, a transcranial approach was required, which was more traumatic, time-consuming and had more complications. The modified and expanded minimally invasive surgical method of transsphenoidal approach to remove invasive pituitary adenomas is composed of various techniques such as surgical microscopy, neuroendoscopy, neuronavigation, electrophysiological monitoring, etc. It is less traumatic and has good therapeutic effect, and can remove huge pituitary adenomas that grow invasively to the cavernous sinus, slope and pterygoid plateau, which is a breakthrough to the cavernous sinus, the original forbidden area for surgery. Practice has confirmed that minimally invasive surgery results in significant improvement of symptoms and loss of function in 80% – 90% of patients after surgery. How to detect pituitary adenoma early Pituitary adenoma can be very harmful to human rest, causing headache and visual field deficit due to the tumor pressing on brain tissue. Although the pituitary gland is small, only 0.6 cm, it has many and complex functions and is the endocrine center of the body. Glandular functions such as thyroid, kidney gland, and gonad are all associated with the pituitary gland, and changes in the gland in turn bring about changes in the whole body. Therefore, pituitary adenomas can cause changes in endocrine function, which can affect changes in other body functions. For example, when pituitary adenomas secrete increased prolactin, women will experience irregular menstruation, amenorrhea, and infertility, and men will experience hypogonadism; when growth hormone increases, adolescents will experience gigantism, and after puberty, they will experience acromegaly and ugly appearance; pituitary ACTH hormone adenomas will cause excessive secretion of adrenocorticotropic hormone, which will also cause hypertension, or cerebral hemorrhage due to hypertension, and osteoporosis. It can also cause hypertension, cerebral hemorrhage, osteoporosis and lumbar spine fracture. If women of childbearing age suddenly have longer menstrual cycles or stop menstruating; if normal people often collide when driving or walking; if they suddenly feel bad sexual function, infertility, enlarged limbs and ugly appearance during their childbearing age or young adults, they should consider that they may have pituitary adenoma and need to go to the hospital as soon as possible, in addition to gynecology, ophthalmology, urology and other related departments for examination, they should also come to endocrinology and neurosurgery to find out whether they have pituitary adenoma. Neurosurgery to check whether pituitary adenoma is present.