Long-term medication is generally required after cardiac bypass surgery, but some of the drugs can be stopped at one year under the guidance of the doctor according to the review results and clinical manifestations. After heart bypass surgery, aspirin and clopidogrel should be taken for 12 months to prevent blood clots, of which aspirin should be taken for a long period of time if not required by the surgery; if there is no abnormality in the review after one year, clopidogrel can be discontinued under the guidance of the doctor if there is a wish to do so. After surgery, according to the blood pressure, blood lipid, blood sugar situation, the general need to take the appropriate antihypertensive, lipid regulation, as well as hypoglycemic drugs, such as bisoprolol, simvastatin, metformin, etc., such drugs are not generally recommended to stop. If there is no obvious palpitations and chest tightness 1 year after the operation, nitrate drugs such as nitroglycerin and isosorbide mononitrate can be discontinued under the guidance of the doctor, but it is recommended to carry them with you, so that you can take them as a first aid in case of any discomfort. It is not recommended to stop taking medication without authorization after cardiac bypass surgery, and it is important to follow the doctor’s instructions to take medication correctly.