Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disease in women of reproductive age, with a prevalence rate of 4% to 12% of women of reproductive age, and 70% of them consulting for infertility problems. Clinical manifestations include menstrual abnormalities, infertility, hyperandrogenism, and polycystic ovarian changes. It may be accompanied by metabolic abnormalities such as obesity, insulin resistance (IR), and dyslipidemia. Since there are differences in the clinical manifestations of this disease, there are also differences in the treatment, which means that the medication should follow the principle of individualization. In this article, we will focus on the treatment of polycystic ovary syndrome combined with infertility. Firstly, regular use of short-acting contraceptives (Dain-35, Maflon, Eucerin) for 2-3 cycles, followed immediately by the use of drugs to promote ovulation (clomiphene, letrozole), regular monitoring of follicular development, and choosing the ovulation period for coitus. Secondly, for obese patients with polycystic ovary syndrome to reduce weight, it is best to use both diet control and exercise enhancement methods, the effect is more obvious. Again, for patients with insulin resistance to take insulin sensitizer at the same time, such as metformin. In addition, recent studies have shown that serum levels of 25-hydroxyvitamin D2 are generally lower in infertile patients than in normal people, so appropriate multivitamin supplementation is necessary.