Prevention and early detection of HPV infection is the prevention of cervical cancer 1. It is now clear that HPV infection is necessary for the occurrence of cervical intraepithelial neoplasia and cervical cancer. 2. Persistent high-risk HPV infection is a major factor in the occurrence of cervical cancer and precancerous lesions. 3. Multiple HPV infections and HPV viral load are closely related to the extent and development of cervical cancer and precancerous lesions. 4, benign lesions to the highest incidence of condyloma acuminata, condyloma acuminata is the second most prevalent sexually transmitted diseases in China, mainly caused by low-risk HPV infection, of which condyloma acuminata caused by HPV-6 and -1 1 infection accounted for 90% of the total. 5, HPV infection after malignant lesions in women with the highest incidence of cervical cancer. 6.Globally, cervical cancer is the first high-incidence malignancy in women, caused by high-risk HPV infection, of which more than 54% of severe heterogeneous hyperplasia and cervical cancer are caused by HPV-16 and 10% to l5% by HPV-18. 7.HPV-16 and -18 types are also important causes of vaginal cancer, vulvar cancer, anal and penile cancer. 8. If HPV-DNA of the same high-risk type is detected twice in a row at intervals of more than one year, it is considered a persistent infection. 9.Only chronic persistent high-risk HPV infection can eventually evolve into cervical cancer. 10.Susceptibility factors for chronic persistent infection include immunosuppression, chronic inflammation and certain HLA genotypes, such as H IV infection or organ transplant patients, combined with other infections such as HSV-2, cytomegalovirus, Chlamydia trachomatis, etc. Other cancer-promoting factors include nutritional status of the body, smoking, use of estrogen and local environmental factors of the cervix. 12.It is especially worth noting that almost all high-risk HPV types have the ability to transform malignantly even when the viral copy number is very low, so this feature is significantly different from other human oncogenic viruses. 13, Cervical heterotypic hyperplasia generally occurs near the migratory zone of the cervical and columnar epithelium and in the peripheral zone. 14, from chronic persistent high-risk HPV infection to the final progression to malignancy often takes 10-20 years, but a few cases, with the exception of 1-2 years can progress to malignancy.