There are many reasons for acne on the forehead and nose, and a clear diagnosis should be made in order to better understand the causes of the disease and choose the best treatment method. If acne grows on the forehead and nose, the most common disease is acne. The causes of acne are as follows: first, genetics; second, excessive secretion of androgens; third, infections such as Propionibacterium acnes; and fourth, hyperkeratosis of the hair follicle opening caused by various reasons. In addition, flat warts and common warts caused by papilloma virus infection, as well as some chronic inflammatory skin diseases, such as seborrheic dermatitis and rosacea, can also be prevalent on the forehead and nose. The most important thing is that it is not just a matter of the skin, but also a matter of the skin’s neoplastic nature, such as fibroma and epithelioma. Therefore, it is important to make a differential diagnosis based on the clinical manifestations and choose the appropriate medication and means of treatment after a clear diagnosis.